“Why Does it Feel Like My Insides are Falling Out?” (Part One)

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As a pelvic floor physical therapist, I am often asked this question by concerned women who may be experiencing pelvic organ prolapse (POP), a weakness disorder of the pelvic floor.  POP is defined as “the descent of one or more of the anterior wall, posterior vaginal wall, the uterus (cervix) or the apex of the vagina (vaginal vault or cuff scar after hysterectomy)” by the International Continence Society.

There are several different types of POP, including:

  • Uterine/cervix prolapse- when the uterus prolapses directly down through the vagina
  • Cystocele/anterior prolapse- when the front vaginal wall is pushed down by the bladder
  • Rectocele/posterior prolapse-when the back vaginal wall is pushed down by the rectum
  • Rectal prolapse- when the rectal tissue prolapses through the anus. This is often related to chronic pushing and straining

Ordinarily, the pelvic floor organs are held in their upright position via intact endopelvic fascia and suspensory ligaments, especially the uterosacral ligament.  Furthermore, the hammock-like levator ani (deep pelvic floor) muscles rest below the organs and prevent them from descending.  Similar to postural muscles, the levator ani muscles provide continuous dynamic support to the pelvic floor, and they contract prior to movement to support the organs during movement.  The ligaments serve as primary support from above and the pelvic floor muscles serve as backup support from below.

Many factors contribute to POP development.  One such cause is pregnancy and childbirth.  In fact, after an individual’s third vaginal delivery, the relative risk for POP development increases significantly.  This risk rises even higher if instruments (forceps or vacuum) were used during delivery.  Even those who have underwent C-section delivery are not necessarily in the clear either.  Pregnancy alone even without vaginal delivery increases the risk of developing POP.  This is due to the loosening effects created by the hormone relaxin which circulates in the blood at increased levels during pregnancy.

Other factors that contribute to POP development include chronic straining (ex. history of constipation), activities involving increased intra-abdominal pressure (ex. jobs that involve heavy lifting), obesity (which increases POP risk 30-50%), lower abdominal surgeries (which may disrupt the ligaments which provide support to the organs), aging, race (POP is seen more frequently in Hispanic women and less in Black/African American), and genetics.

POP severity is graded on a scale from zero (no prolapse) to four (the organ has completely extruded from the body, which is rare and requires surgery).  Approximately 50% of women who have given birth experience POP at some point during their lives, and it is one of the leading reasons for women to undergo hysterectomy.  In fact, 11.1% of community dwelling women undergo POP or incontinence surgery, however physical therapists are aiming to decrease these numbers through education about conservative treatment.

 

To Be Continued…

Connecting the Dots

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Polycystic ovary syndrome (PCOS) is a condition characterized by a set of symptoms which are the result of increased androgen production by the ovaries.  Androgens are hormones that contribute to the development of male characteristics.  These symptoms include irregular or infrequent menses, heavy menses, pelvic pain, fertility challenges, and excessive facial and/or body hair.  PCOS is also associated with adult onset (type two) diabetes, heart disease, obesity, sleep apnea, and endometrial cancer.  It is the most common endocrine disorder found within women aged 18-44.

Two important hormones ordinarily released by the ovaries include estrogen and progesterone.  Treatment for PCOS includes modified ovarian hormones (ex. oral contraceptives which generally contain estrogen and progesterone) to counteract the effect of the androgens.  Another approach to treating PCOS includes anti-androgen drugs.

A third and new approach being researched is modified adrenal hormones.  The adrenal hormones include adrenaline and steroids (aldosterone, cortisol, and the hot topic of the day- androgens).  What do the adrenal glands have to do with ovaries?  That is an excellent question.  The answer, which is also the reason why this approach is being explored, is because a recent study conducted by the National Institute of Health’s (NIH), results released June 27, 2016, suggests that there may be a link between PCOS and adrenal gland disorder.  Previous research has revealed that the adrenal glands of some women with PCOS produce increased amounts of androgens.  In this study, 38 women with diagnosed PCOS comprised the experimental group, and 20 women without PCOS served as the control group.  Almost 40% (15 of the 38 women in the experimental group) demonstrated increased adrenal gland hormone production.  Furthermore, on average, the size of these women’s adrenal glands were smaller than average.

 

These findings reminded researchers of micronodular adrenocortical hyperplasia (MAH), a condition characterized by formation of little nodules on the adrenal glands.  These nodules begin to produce adrenal hormones independent of the adrenal glands.  The new alternative hormone source “allows” the adrenal glands to get lazy, slack off in their own hormone production, and shrink.  The similarities between women with MAH and a decent number of women with PCOS, particularly smaller adrenal glands, struck the researchers.

What percentage of women who experience PCOS are actually also experiencing adrenal gland dysfunction?  Is there a connection in the pathology and etiologies of the two disorders?  Perhaps most importantly, can the population of women with PCOS who also demonstrate adrenal hormone overproduction benefit from adrenal hormone therapy?  Connecting the dots between the ovarian-adrenal connection may guide and facilitate future research and treatment.