Morning Sickness- A Hidden Blessing

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One of the many unpleasant symptoms that often accompanies the first trimester of pregnancies is morning sickness.  Typically, the strong feelings of nausea (at times accompanied by vomiting) is worst at the start of the day and towards the beginning of pregnancy.  But is morning sickness all bad?

For decades, researchers have attempted to answer this question and find the silver lining in the nausea.  Hook and Profet proposed that morning sickness protects the developing fetus harmful chemicals in foods by physically forcing the pregnant woman to expel them.  Examples of such chemicals are toxins in certain strong-tasting vegetables, alcohol, and caffeine.  In fact, this may explain and be linked to certain food aversions experienced by some pregnant women.

It has also been proposed that women who experience morning sickness, especially accompanied by vomiting, are less likely to miscarry.  This possible inverse relationship was recently explored at the National Institutes of Health’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).  The goal of the study was to provide hard core evidence that morning sickness indicates a healthy developing pregnancy and decreased risk of miscarriage.

In the study, Dr. Hinkle and her team investigated data from a previous clinical trial called the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial (for more information, please refer to this link).  The EAGeR trial attempted to answer the following question: If a woman has experienced one or two previous miscarriages, does taking prophylactic aspirin prevent miscarriage in future pregnancies?  This innovative research was the first in its kind, as it had participants keep a detailed account of nausea and vomiting symptoms early in pregnancy in a population of women who had all experienced previous miscarriage(s).  Participants kept meticulous journals during weeks 2-8 of their pregnancies documenting nausea and vomiting.  After the eighth week, the women kept track of the same symptoms on a monthly basis through the 36th week of pregnancy.

The results of the study supported the aforementioned hypothesis.  Of the 797 women who participated in EAGeR, 76.4% of the participants completed their pregnancies.  Unfortunately, the remaining 188 women (23.4%) experienced miscarriages.  Researchers found that 57.3% of the participants reported symptoms of nausea and 26.6% of the participants reported nausea with vomiting.  Ultimately, these women were 50-75% less likely to suffer a miscarriage compared to the women who did not experience the same symptoms.  Although the women probably did not appreciate their unpleasant and undesirable symptoms at the time, those very symptoms were benefiting and protecting their babies.  In other words, that which was previously viewed in a negative light was actually extremely positive.

Hopefully, this ironic research discovery will help pregnant women withstand and, dare I say, appreciate the hidden blessing which we call morning sickness.  In the words of Victor Frankl (Man’s Search for Meaning), “In some way, suffering ceases to be suffering at the moment it finds a meaning, such as the meaning of a sacrifice.”  May this newfound understanding of morning sickness, one of the many sacrifices mothers make for their children, provide tolerance, encouragement, and meaning to expectant mothers.    

Zapping Zika

 
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Recently, the National Center for Advancing Translational Sciences (NCATS), a subsidiary of the National Institutes of Health (NIH), announced exciting news in the fight against Zika.  Not only have they made progress regarding potential medication, but they have also begun researching a possible vaccine to enable immunity against the devastating disease.

 

The Zika virus, whose name is derived from the Uganda Zika forest (where the virus was first identified in 1947), is spread by diurnal Aedes mosquitos.  Prior to 2007, the virus was mostly contained within limited parts of Africa and Asia.  However, the virus spread east between 2007 and 2016 across the Pacific Ocean to Latin America and beyond.  To date, Zika has been reported in over sixty countries.  Adults who are infected with the virus may develop a fever which can be alleviated with acetaminophen.  Furthermore, Zika can result in the development of Guillian-Barre Syndrome or other neurological dysfunction in adults.

 

Additionally, a truly dangerous feature of the Zika virus is that it frequently attacks the brain cells of the developing fetus in utero.  This may lead to fetal microcephaly, small sized head due to an underdeveloped brain, or brain malformations.

 

Fortunately, researchers at John Hopkins University and Florida State University have been developing a medication to treat the virus.  The compound under investigation contains both emricasan (a drug being explored for its potential benefit against certain liver diseases) and niclosamide (an FDA-approved medication used to treat worm infections).  Finally, several cyclin-dependent kinase (CDK) inhibitors were associated with decreased brain cell death in the NCATS research.  (CDK inhibitors interfere with cellular reproduction, and this class of drugs is often used to treat cancer and prevent cancer cells from spreading.) It is unclear whether or not the medication is safe for usage during pregnancy.  Further research is warranted to determine safety for expectant mothers.

 

Furthermore, the NIH released on August 3, 2016 that they have initiated clinical trials with a potential Zika vaccine.  The National Institute of Allergy and Infectious Diseases (NIAID), a different branch of the NIH, has gathered approximately eighty volunteers (aged 18-35) who are being followed at three different study centers.  Researchers are analyzing the immune system’s response to the proposed vaccine.  However, the clinical trial is merely in the early stages, so results will probably be unavailable for some time yet.

Fortunately, advances in potential Zika prevention and treatment are underway.  Until then, it is wise to plan vacations accordingly, especially if you are attempting to become pregnant in the near future.  Please refer to this information released by the Centers for Disease Control and Prevention for more detail.